The OPP say Highway 9 is closed near Walkerton after a serious two-vehicle collision.
Emergency services were on scene just prior to 3 p.m. at Highway 9 and Bruce Road 3 for the incident.
The OPP say in a social media post the extent of injuries is unknown.
Highway 9 is currently closed between Bruce Road 12 and Sideroad 5 in the Walkerton area.
Drivers are being advised to avoid the area.